Pharmacokinetics & Pharmacodynamics

The Pharmacokinetics and pharmacodynamics (PK / PD) unit is a center of

excellence for pre-clinical studies aimed at the definition of:

Absorption

Distribution

Metabolism

Elimination

Toxicity

 

Pharmacokinetic analyses are conducted through development, validation and implementation of quantitative bioanalytical methods using High Performance Liquid Chromatography (HPLC) and LC-Mass Spectrometry (MS). Data analysis, models and statistical interpretation of results are performed using standard pharmacokinetic software (WinNonlin® or Kinetica).

 

 

Experimental Activities

Analyses
Plasma and tissue stability
Plasma protein binding
Repartition coefficient
Metabolic Stability
Perfusion for rat organ (liver, kidney, muscle,heart)
ADME in vivo studies (mice, rats)
Bioavailability / bioequivalence evaluation
Tissue Exposure
Excretion (urine, bile)